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KMID : 1059520070510010043
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Journal of the Korean Chemical Society
2007 Volume.51 No. 1 p.43 ~ p.50
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In Vitro Stability of Liposomes Containing Newly Synthesized Glycolipid
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Song Chung-Kil
Jung Soon-Hwa
Seong Ha-soo
Cho Sun-Hang
Shin Byung-Cheol
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Abstract
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Liposomes having particle size from several tens to hundreds nanometers are efficient carriers for injectable
drug delivery. Enhancement of liposome stability in bloodstream has been studied because of its relatively short circulation
time and fast clearance from human body by reticuloendothelial system (RES) in blood vessel. In this study,
new disaccharide-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) derivatives in which lactose or sucrose as
the disaccharide molecule was conjugated covalently to DSPE were synthesized. Liposomes of which surface had disaccharide
molecules were prepared by incorporating the disaccharide-DSPE into liposomes as one of their lipid components.
Particle size of the prepared liposomes was approximately 100 nm. The liposomes of which surface were
modified with the disaccharide-DSPE showed -25 mV of zeta potential value due to the presence of hydroxyl groups
on their surface, while the unmodified control liposomes showed -10 mV of zeta potential value. Loading efficiency of
model drug, doxorubicin, into liposomes was about 90%. Stability of the disaccharide-modified liposomes in vitro was
evaluated by monitoring the amount of protein adsorption and particle size of the liposomes in serum. Disaccharide-modified
liposomes were more stable in serum than unmodified control liposomes or polyethyleneglycol (PEG)-modified
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KEYWORD
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Liposome, Disaccharide, Stability
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